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It is a designation used primarily by the FDA (Food and Drug Administration) for products, often in vitro diagnostic (IVD) components like reagents or instruments, that are in the laboratory research phase of development and are not intended for clinical diagnostic use

In the report, a subgroup analysis that divided patients into different baseline HbA1c groups suggested that dental care treatments may lead to greater improvement in glycemic control for patients with higher baseline HbA1c levels

Moertel et al., 1985)

However, the general treatment protocol usually includes 3 to 5 sessions performed at intervals of two to four weeks, to achieve the desired results such as deep hydration and improved skin elasticity