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Similar morphological features are typically related to a reduction in the absorption surface area and limited digestive efficiency in the absence of prepared NPs during embryogenesis

There is few clinical evidence of the effect of agomelatine in reducing overall depressive symptoms: results show agomelatine's higher response and lower remission rate compared to placebo (96, 97) and its similar efficacy compared to other antidepressants (i.e., paroxetine, fluoxetine, sertraline, escitalopram, and venlafaxine) (97, 98)

10.1007/s00383-023-05376-3 77

This study showed that a subgroup of patients using this innovative de-escalating approach omitting chemotherapy received a pCR response, and around one-third of the patients achieved a promising 3-yeat iDFS from surgery with chemotherapy-free therapy