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In the Phase 2 retatrutide trial ( Jastreboff et al., NEJM 2023 ), body-composition imaging showed fat mass falling substantially more than lean mass, meaning the majority of the weight lost was fat

The enzyme plays a crucial role in the production of red blood cells, the functioning of the nervous system, and the synthesis of DNA

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These results indicated that CSD would impair the hepatic redox homeostasis and contribute to the development of ferroptosis, which could effectively be rescued by supplementation with ALA