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A deficiency can be caused either by diseases that increase the need for glutathione, or by nutrient deficiencies required for synthesis, but also by diseases that inhibit its formation.Additionally, smoking increases the use rate of glutathione, both in the detoxification of nicotine and in the neutralization of free radicals produced by tobacco smoke

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Mosier S, Apfelbaum S, Byck P, Calderon F, Teague R, Thompson R, et al

Though its used to treat everything from menstrual cramps to high blood pressure, evidence regarding its efficacy and safety is lacking