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DNA nanostructures have demonstrated promising potential in translational medicine, specifically in novel applications like targeted drug delivery, biosensing, molecular imaging, and nucleic acid therapeutics 131

For instance, post-hoc analyses of pre- and post-treatment biopsy samples from Ewing sarcoma patients treated with either IGF-1R mAb or a combination of cixutumumab and the mTOR inhibitor temsirolimus revealed that median PFS and OS was better in phospho-IGF-1R-negative patients