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The term scatter factor was later introduced independently in 1985 by Stoker and co-workers, as they discovered a protein interrupting the intracellular junctions of epithelial cells thereby promoting their migration in a paracrine manner and promoting an invasive phenotype [4]

For 13 C-labeled metabolites, we retrieved their metabolic reaction relationship from metabolic reaction network curated using the KEGG database, which results in reaction pairs (RPs) between labeled metabolites (Fig