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We detected minimal activity of ABHD11 against succinyl esters, but this analysis was hampered by the spontaneous hydrolysis of the succinyl compounds

This link between TNF- and ROS adds another dimension of complexity to the TNF signalling network, as ROS act on numerous proteins required for the regulation of cellular homeostasis, including proteins that mediate cell proliferation, survival, death, differentiation, DNA repair and metabolism 30

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NNMT catalyses the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, the precursor in the NAD+ salvage pathway