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doi: 10.3389/fnsys.2011.00010 105 SchumannC

TB500 appears to be well-tolerated in the short term, with minimal side effects reported in most anecdotal and veterinary cases

J., Choi, I., & Leem, K

Hence, in more advanced TBM stages there is less CSF lactate and therefore fewer energy substrates available for microglia activity, and decreased protection of neurons