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It does not, and the FDA's reasoning here is worth taking seriously

While encouraging, this studys retrospective design, lack of placebo control, small sample size, and subjective outcome reporting limit its interpretability

Strength restoration improves during recovery cycles

A structural explanation for these findings was provided from our previous cryo-EM structures of CT(Pro32) and rAmy(Tyr37)-bound AMYRs structures where the bulky phenolic side chain of Y37 rAmy forms perpendicular stacking interactions with W79 ECD 15 , and additional interactions with the respective RAMP protomer that are likely important for selectivity of rAmy for AMYRs over CTR