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Oral supplements have to pass through the digestive system and may not be absorbed efficiently, especially in people with gastrointestinal conditions like celiac, Crohns, or gastritis

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For severe deficiency, patients get 1,000 mcg daily for the first week

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This non-linear dose-response is characteristic of peptides that operate through receptor saturation rather than systemic hormonal signalling

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Precautions General Precautions: Vitamin B12 deficiency that is allowed to progress for longer than 3 months may produce permanent degenerative lesions of the spinal cord

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