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The metabolically stabilized 6-AH family member, D-Nle-Tyr-Ile-NH-(CH 2 ) 5 -CONH 2 , had a t| /2 in blood of 80 min compared to the parent compound Norleual (Nle-Tyr-Leu-T-(CH 2 -N) 3 -His-Pro-Phe, SEQ ID NO: 1), which had a tj 2 in blood of Cm ax concentration in plasma extrapolated to time zero (Co), terminal elimination half-life (ti 2 ), volume of distribution (Vd), and clearance (CL)

Zhao et al., 2018), has been implicated as an essential factor in the protective microglial response to herpesvirus infection, with increased phagocytosis of infected neurons (Fruhwrth et al., 2023)

The peptide as well as its Cu (II) chelate have anti-inflammatory and tissue remodeling properties

The consensus among experts is that the majority of studies performed on humans are focused on topical application