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Next, pathways enriched in the DEGs were assessed with gene set enrichment analysis (GSEA) (Figure S4E-G) (for complete results, see Table S4)

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It induces G1 cell cycle arrest and apoptosis in GBM cells and GSCs by downregulating c-MYC, Bcl-2 and other oncogenes, and upregulating p21 and p27, and significantly prolongs the survival of mice bearing orthotopic GBM xenografts (Pastori et al., 2014)