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This increased activity promotes calorie expenditure and fat burning, making it an essential component of successful weight loss

Kikuchi R, Hirano T, Watanabe K, et al

However, our data suggested that RNF4-based BRD4 degrader CCW28-3 did not function through an RNF4-dependent pathway, as BRD4 degradation was observed in RNF4-deficient cells