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Notably, GSH is more likely to bind to the L2 and L4 regions near CuA

Cell 185 , 831846.e14 (2022)

Notably, the key components of the IL-6/JAK signaling pathway, including Jak2 and Il6ra, were significantly downregulated, which aligned with the observed suppression of JAK2/STAT3 signaling at the protein level