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Salivary microbiome: Univariable analysis (FigB) shows that salivary Streptococcus , Treponema, Enteroccaceae & Capnocytophagia were higher and commensals such as Veillonellaceae & Lachnospiraceae spp were lower in those who were ultimately hospitalized

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The human data, while limited, is directionally aligned with decades of preclinical work across multiple species

Figure 3 The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammatory vesicles are a complex of multiple proteins that play key roles in regulating the innate immune system and inflammatory signaling processes (164)