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The vaccines were found to reduce pathology after SARS-CoV challenge unless the S protein of the vaccine included amino acids 597603, suggesting an epitope-specific basis for the induction of lung pathology

As with CYP2E1, there are substantial inter-ethnic differences in CYP2D6 across populations, ranging from complete loss of function or reduction in functional activity (2570% of the population, dependent on ethnic origin and geographical location) to extensive, ultra-rapid metabolisers (1.59.3% of the population) (see Table 3 in the supplementary data for a summary of the evidence) [17, 38]

Some proteins, such as TRIM31 and Gp78, mitigate liver damage by promoting lipid turnover and reducing inflammation