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J Cell Sci 120(Pt 5):885894 Sauer H et al (2000) Role of reactive oxygen species and phosphatidylinositol 3-kinase in cardiomyocyte differentiation of embryonic stem cells

This variability is shaped by a complex interplay of biological and lifestyle factors, including baseline tissue creatine concentrations, muscle fiber type composition, bone remodeling capacity, neuro-energetic status, habitual dietary creatine intake, sex, age, and physical activity level [80]

It has powerful antioxidant activity and can cross the BBB (Tables 2 and 3) 165 where it has a positive impact on brain function

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