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Firstly, angiopep-2 allowed the nanoparticles to cross the BBB through RMT by recognition of LRP1 on the BBB and, secondly, angiopep-2 increased the accumulation of nanoparticles in glioma cells thanks to recognition of the LRP1 on the glioma cells surface

Uro A, an intestinal microbial metabolite of ellagitannin, inhibited phosphorylation of AKT and p70S6K through the PI3K/AKT/mTOR pathway and induced strong antiproliferative and proapoptotic effects in PDAC, along with reduced levels of infiltrating immunosuppressive cell populations such as myeloid-derived suppressor cells, tumor-associated macrophages, and regulatory T cells

(2018) Meta-analysis of randomized controlled trials of 4 weeks or longer suggest that curcumin may afford some protection against oxidative stress