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Description

Ferroptosis contributes to follicular depletion, ultimately leading to DOR (Figure 4B)

pmid:20458016 4

The molecular systems involved include actin cytoskeletal remodeling and integrin signaling, with focal adhesion pathways facilitating attachment of fibroblasts to collagen

Hence, the intracellular redox state, which is characterized by the levels and ratios of oxidized (GSSG) and reduced (GSH) glutathione, is regarded as a significant indication of the cellular health (Lu 2013)