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In the female offspring, mitochondrial fusion markers on P1 suggest increased mitochondrial regeneration, while in adults increased mitochondrial fission and autophagosome markers were observed, with high levels of MnSOD and OXPHOS complex I suggesting an increase in energy demand and oxidative stress, thereby more mitochondrial turnover (Twig et al., In the developing brain, substantially high energy demand increases the need for glucose, oxygen and cerebral blood flow (Hagberg et al., Mitophagy is a crucial process to maintain mitochondrial integrity, where damaged mitochondria can be degraded and the intact components can be recycled to generate new functional mitochondria (Benard and Karbowski, Here in the newborn male SE offspring, both fission and autophagosome markers were increased without changes in the fusion marker, suggesting the mitochondrial damage by maternal SE is irreparable
Orphanet J Rare Dis
Investigao sobre o envelhecimento saudvel: Um artigo publicado na revista *Science* em 2023 relatou efeitos na esperana de vida e na esperana de vida saudvel em modelos animais, mas as alegaes de efeitos antienvelhecimento em seres humanos so prematuras sem ensaios clnicos mais slidos que avaliem os resultados em seres humanos
