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However, IGF1 has no significant impact on muscle mitochondrial function, indicating that the deficiency of IGF1 in male mice has different roles on tissue mitochondrial function between the center and periphery circulation (Pharaoh et al., 2020)

This suggests that Piezo1 channels are associated with normal neuronal development, nociception, and pathological conditions ( 3.1 Effects of Piezo1 under normal conditions Piezo1 regulates the number of neuroepithelial cells, and it is also involved in maintaining their integrity

P 1300 essential cellular proteins, resulting in cell death [11, 15]