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It is activated in response to a wide variety of signals, such as those conveyed by Rap1A and Ras, through a mechanism that involves its C-terminal Ras association (RA) domains (RA1 and RA2)

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The author later injected serum from patients with GD into himself and his colleagues to show the presence of stimulating activity

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The reduced iWAT mass was accompanied by a decrease in adipocyte size, indicating a mitigation of hypertrophy expansion (Fig

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