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49th Annual Meeting of The Society of Thoracic Surgeons:290, 2013

In patients with renal, cardiac or hepatic impairment, caution is required since the use of NSAIDs may result in deterioration of renal function

The distribution of 4-HNE and similar alkenals has pharmaco-toxicological relevance: owing to the intrinsic toxicity of aldehydes, it is important to know their metabolism and fate: Alary et al