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International Journal of Biological Sciences [electronic Resource]

and recall bias, given its casecontrol design.] The MCC-Spain study, a casecontrol study considering multiple cancer sites and conducted between 2008 and 2013 (Palomar-Cros et al., 2023), investigated associations between use of artificial sweeteners (assessed via FFQ), separated into aspartame and other artificial sweeteners both derived from ASBs, tabletop sweeteners, and consumption of gaseosa (an artificially sweetened soft drink commonly consumed in Spain), and their association with risk of breast (1510 cases) and prostate (972 cases) cancer, using 3629 population controls

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Two-tailed tests were performed unless testing a direction hypothesis, in which case a one-tailed test was used