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In addition, the PPAR-PGC-1 axis is also a significant regulator of mitochondrial biogenesis in many other vital organs, including the brain, liver, kidney, or adipose tissue [25, 28, 30]

Many antidepressants are selective serotonin reuptake inhibitors (SSRIs), which work by preventing the reabsorption of serotonin, thereby increasing extracellular levels of the hormone