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Similarly, diallyl trisulfide (DATS), a naturally derived HDACi, increases histone acetylation, suppresses tumor angiogenesis, and significantly enhances radiotherapy efficacy in preclinical GBM models without inducing hepatotoxicity ( Collectively, these studies identify acetylation as a central epigenetic hub that integrates chromatin remodeling, signal transduction, and tumorimmune interactions to drive radioresistance

Since animal products are the richest sources of B12, B12 supplements are more commonly recommended for those who follow a vegan or vegetarian diet, as opposed to a Paleo diet

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