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10.1016/j.neuro.2005.01.003 Neurotoxicology 51 Ramos-ChvezL

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Depletion of bioavailable nitric oxide in the vasculature by excess oxidants causes endothelial dysfunction, which is characterized by a decrease in endothelium-dependent vasodilation while retaining the ability of vascular smooth muscle cells to vasodilate in response to nitric oxide donors, such as sodium nitroprusside [53]