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Conversely, our observation of elevated GSSG in cells lacking MPC1 (Figure 8B) suggests that, at a minimum, GSSG is not incompatible with diminished sensitivity to NAFLD

Although this was an example of non-cancerous disease, it can provide insights that such failures can happen in the treatment of cancer using RNA therapeutics

Tryptophan metabolism in central nervous system diseases: Pathophysiology and potential therapeutic strategies

[5] The severity of SCD is generally less when compared to PCD as the plasma carnitine levels are relatively higher and hence easier to manage.[3][8]Patients with SCD, in general, do not have hepatic or cardiac involvement