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17 Multiple trials have demonstrated comparable efficacy of oral ALA in the treatment of neuropathic pain from DPN

Funding This work was supported by the National Key R&D Program of China (grant number: 2023YFC3404100, 2023YFC2506400), and National Natural Science Foundation of China (grant number: 82325042, 82203860), and Shanghai Municipal Education Commission Scientific Research Innovation Project (grant number: 2023-05-50), Wu Jieping Medical Foundation Research Project (grant number: 32067502023-18-29)

Conversely, ALC boasts an added acetyl group that enables it to cross the blood-brain barrier

Protein bands were visualized with an ECL detection kit, and the intensity of protein bands was quantitated by Image Lab 6.1 software (Bio-Rad Laboratories, Hercules, CA)