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doi: 10.1126/science.aaa3177 160 GreeleyE

Brindle, Joshua D

Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells

Our experiment carried out in ex-vivo organoids derived from intestinal crypts demonstrated that ROS induces cell death in wild type Apc-expressing but not in Apc-mutated ex-vivo organoids