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First-line treatments for osteoarthritis of the knee include: Injection therapy is a second-line treatment for arthritis

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Although both studies explored the association of TMPRSS6 polymorphisms with DM, finding that rs855791 and rs4820268 were linked to iron metabolism markers and the former showed sex-specific risk differencespossibly due to metabolic, hormonal, and physiological disparities between sexesthey had limitations including uncontrolled ethnic variations, sample constraints, and uninvestigated mechanisms beyond iron metabolism

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