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Hepatocyte growth factor as an enhancer of nmda currents and synaptic plasticity in the hippocampus. Neuroscience 128(1): 155-62

The following relevant parameters were determined where possible: area under the concentration-time curve from time zero to the last time point (AUC 0-last ) or extrapolated to infinity (AUC 0- ), C max concentration in plasma extrapolated to time zero (C 0 ), terminal elimination half-life (t 1/2 ), volume of distribution (Vd), and clearance (CL)

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Studies on HepG2 and HuH-7 cells demonstrated that the cells synthetised and secreted also IGF-2 and inhibition of the protein production resulted in a reduced cellular proliferation (87)