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Culture media consisted of 10 g/L glucose, 1 g/L yeast extract, 5 g/L (NH 4 ) 2 SO 4 , 2 g/L KH 2 PO 4 , 0.5 g/L MgSO 4 7H 2 O, 0.1 g/L CaCl 2 2H 2 O, 0.02 g/L FeSO 4 7H 2 O, 0.01 g/L ZnSO 4 7H 2 O, 0.005 g/L CuSO 4 5H 2 O, 0.001 g/L MnCl 2 4H 2 O, 2.5 mL of 70% H 2 SO 4 and 0.5% (v/v) Antifoam 204 (Sigma Aldrich, St

(48) reported that daily administration of 50 mg/kg curcumin (intraperitoneal) effectively prevented PD-like symptoms induced by rotenone in mice, likely due to its inhibition of microglial NF-B-NLRP3 inflammasome activation and reduction of pro-inflammatory cytokines such as IL-1 and IL-18

J Enzym Inhib Med Chem

Thus, through high consumption of NAD + , CD38 also indirectly impacts the activity of other NAD + -consuming enzymes such as sirtuins 52