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J Biol Chem 1995, 270: 12301237

As it has often been alleged that the South, without any overt aggression upon its political rights by the North, but for the sake of mere principle or the shadow of wrong, took the decisive step of secession which inaugurated the bloody drama of the war, in justice to the South it is proper to enumerate some of the grievances of which it complained

Currently, several drugs targeting IL-6 signaling such as IL-6 inhibitors (siltuximab, clazakizumab, sirukumab, olokizumab) and IL-6R inhibitors (tocilizumab, sarilumab, levilimab) are available