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That most anti-cancer drugs are poor substrates for GSTP indicates that the role of elevated GSTP in many tumor cell lines is not to detoxify the compounds, but must have another purpose

5-Thio-D-glucose, after metabolic breakdown, releases free sulfhydryl (-SH) groups, which can lower the cellular oxidation level and thus reduce radiation damage (187), while also inducing DNA damage in tumor cells to increase radiosensitivity (188)

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