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The functional consequences of accumulated mtDNA damage are profound, as oxidization, mutation, or deletion of mtDNA molecules can impair the assembly and function of respiratory chain complexes, leading to deficient ATP synthesis and increased ROS production [19]

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10.1002/advs.202303617Beyond extracellular vesicles: hybrid membrane nanovesicles as emerging advanced tools for biomedical applicationse2303617 189 SunT.PikiolekM.OrsiniV.BerglingS.HolwerdaS.MorelliL.et al (2020)

Each ADC is essentially a combination of a large biologic (the antibody) and a small-molecule drug, and this dual nature means that analytical and quality control teams must characterize both components as well as the conjugated product