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At steady state, however, cellular IL-1 expression is often undetectable and the ligation of pattern recognition receptors (PRR), such as Toll-like receptors (TLRs), is required to induce transcription of inactive pro-IL-1

On the contrary, treating these cells with blebbistatin influences their morphology, confining the adhesions to the extreme cell periphery, causing actin stress fiber formation and enhancing contractility, thereby stimulating ASC myofibroblast transition (Seo et al., 2020)

Oral supplements are taken daily, while injection schedules depend on the individuals goals and the healthcare providers recommendations

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