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Doxil--the first FDA-approved nano-drug: lessons learned

Of the six studies that measured co-factors of the -glutamyl cycle or trans-sulphuration pathway, five studies showed elevated levels of vitamin B6 in children with autistic disorder or autism spectrum disorders compared to controls [73, 76, 87, 92, 93], one showed a decrease in erythrocyte selenium in children with autistic disorder [78] and another showed no change in whole blood selenium in children with an autism spectrum disorder compared to controls [87]

Cell 184 , 23842393.e2312 (2021)

Reintroduction of human occludin reverses many of these changes, including restoration of monolayer morphology, claudin-1 expression, and partial recovery of transepithelial electric resistance (TEER) (Li and Mrsny, 2000)