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In the photographic assessment score, there was no statistically significant difference between the placebo group and the 0.5 mg/ml AR68 treatment group compared to the baseline, but in the 5 mg/ml AR68 treatment group, a significant improvement was confirmed at 16 weeks (0.159 0.358) and 24 weeks (0.250 0.551)

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In vitro, isolated PSCs in the high-glucose group expressed higher levels of -SMA and collagen I and had a higher cell proliferation rate