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doi: 10.1155/2018/8173983 233 YuGChoiYKLeeS

It arises from an abnormally expanded CAG trinucleotide repeat encoding the elongated polyglutamine (polyQ) within exon 1 of Huntingtin ( HTT ) gene, which results in the production of toxic mutant huntingtin proteins (mHTT) that accumulate in neurons, particularly in the striatum and cortex ( HTT gene normally contains 10 to 35 CAG trinucleotide repeats, while HD patients exhibit more than 36 repeats

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In 2011, the transmembrane glycoprotein CD44, a cancer stem-like cell marker, and more precisely the CD44 variant (CD44 v ) capable to bind hyaluronan has also been described to interacts and stabilizes system (Figure 1)