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Podocytes, a cell type playing a major role in glomerular filtration barrier integrity, has been shown to display ferroptosis activation upon high glucose exposure through the antioxidant molecule peroxiredoxin 6 (Prdx6) (65)

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These carriers can be engineered for surface modification with ligands targeting dopaminergic neurons or inflamed brain regions, enabling precision delivery and minimizing off-target toxicity (Naqvi et al., 2020