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10.1002/phar.1456 187 KlahrS.YatesJ.BourgoignieJ

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The nanoparticles, coloaded with doxorubicin and hydroxychloroquine (HCQ), released their cargo within acidic lysosomes, where doxorubicin exerted cytotoxic effects, and HCQ blocked protective autophagy and reprogrammed M2-like TAMs to the M1 phenotype by activating NF-B and increasing TNF- and IL-6 secretion

The common alkaloids include pyrrole, pyridine, quinoline, isoquinoline, indole, imidazole, purine, anisodamine, terpenoids, steroids, organic amines, and so on and the chemical structures of these alkaloids are shown in Figure 4