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Route, concentration, formulation, copper coordination and tissue exposure are materially different

Toxicol ., 8: 46-51

Among these, ionizable lipids have been proposed to elicit endosomal rupture 17 , leading to activation of the NOD-like receptor protein 3 (NLRP3) inflammasome 18

This fibrotic transition, often associated to aging (183), obesity (184) and diabetes (185), markedly impairs cardiac function through multiple mechanisms (182)