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Natural polyphenols like castalagin (145) and cranberry proanthocyanidins (146) act as prebiotics, reshaping gut microbiota to alter BA profiles (e.g., increasing taurine-conjugated BAs or reducing local BA accumulation, respectively) and exert anti-tumor effects or enhance ICI responsiveness

First the CAR T-cell-therapy-associated Toxicity (CARTOX) Working Group comprising investigators and representatives from multiple institutions, published consensus guidelines for management of CAR-T-related toxicities including CRS []

These data indicate that NO has a substantial impact on the remodeling of glucose oxidation through the TCA cycle in stimulated macrophages (Fig

Antioxidant activity and inhibition effect on the growth of human Colon carcinoma (HT-29) cells of esculetin from cortex fraxini