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micropetrosis and the canalicular system disruption cause this, leading to bone fragility

Additionally, ERCC4 has been implicated in nucleotide excision repair (NER)

Under in vitro conditions, disruption of Syns tertiary ensemblesthrough charge neutralization (acidic pH or Ca 2+ addition), C-terminal truncation, or Syn-S129p could expose the hydrophobic (NAC) region and transform it into a metastable, reactive state 15,68