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This emphasizes the need to develop effective protocols for disease prevention by understanding these relationships (Kane et al., 2011

This leads to the initiation of mitochondrial oxidative stress, which is amplified by the activation of c-Jun N-terminal kinase (JNK), resulting in mitochondrial dysfunction and opening of mitochondrial permeability transition pores

(ii) the uptake and distribution of melanosome in keratinocytes and (iii) melanin and melanosome degradation and turnover of "pigmented" keratinocytes 5

The combination of hydration, anti-inflammatory medications, and specific vitamins can provide significant relief when traditional treatments aren't cutting it