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PDE4 Inhibitors Phosphodiesterases (PDEs) belong to the class of enzymes that metabolize the intracellular second messenger cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)

Cao, W, Kou, F, Hu, W, Hu, L, Nie, J, Dai, L, Zhang, J, Rui, J, Knetki-Wrblewska, M, Antonoff, MB , Fang, J, Wang, Y

Consistent with the time course data (Fig 1A and 1B), a strong neutravidin-HRP signal was detected for GSTP1 from MCF7-V5_GSTP1 cells metabolically labelled with -alkynyl-palmitate (Fig 1C, left most lane)

We postulate that the same may hold true for Se-based compounds, whereby using bespoke complex molecules that target the intended matrix, therapeutic concentrations could be delivered in a controllable manner yielding more favourable results