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Up to 50% of malignant peripheral nerve sheath tumors arise in patients with neurofibromatosis type 1 (NF1), fewer than 10% of malignant peripheral nerve sheath tumors are radiation associated, and the remainder are without a known genetic predisposition ('sporadic' form)

In contrast, no significant enrichment of genes involved in the mTOR signaling pathway was detected (Figure 3A)

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Research has also examined its potential role in appetite regulation and weight management