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CDK5-mediated tau phosphorylation CDK5 belongs to the family of cyclin-dependent Ser/Thr protein kinases (CDKs) and carries out the activation and maintenance of numerous physiological functions in the nervous system, including neurite and axon growth [43]

Headline results announced in December 2024 and presented in full at the American Diabetes Associations 85th Scientific Sessions in June 2025, with simultaneous publication in the New England Journal of Medicine, showed that CagriSema produced a mean weight reduction of 22.7% at 68 weeks, significantly outperforming placebo