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Levodopa is a precursor to dopamine that crosses the BBB to be metabolized and converted into dopamine, mitigating some motor dysfunctions such as rigidity, bradykinesia, and tremors 12,51

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Although age and sex were not included as covariates in the PERMANOVA models, participants were age- and sex-matched at recruitment

Notably, this review provides a comprehensive analysis of the interplay between ferroptosis regulation and the tumor immune microenvironment, highlighting a promising ferroptosis-immunotherapy combination strategy with clinical translation potential for GBM treatment